HCID 22678421, compound → HCID 22678656, compound

HRID 1837725Notes

Reaction equation

HRID 1837725 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13](/[CH:16]=[CH:17]/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1.[H][H]>C(O)C.[C].[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[CH2:12][CH2:11]2)=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

5

Reactant 2

HCID 22678421HCID 22678421, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22678656HCID 22678656, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

332 mg of 1-[(2-methoxy-3-pyridyl)methyl]-4-[(E)-2-(2-pyridyl)-1-ethenyl]piperidine obtained in Example 29 and 79 mg of 10% palladium-carbon powder (water-containing product) were suspended in 5 ml of ethanol. After replacing the atmosphere of a container with hydrogen, the mixture was stirred at normal temperature under normal pressure for 30 minutes. The reaction solution was filtered, and the filtrate was evaproated, to give 234 mg of the title compound as a colorless oil.

Workup

  1. filtrationThe reaction solution was filtered

Sources & evidence

ORD record
ord-c69675b1200b4f919afd7c61dde37392
Source dataset
uspto-grants-2004_08
Patent number
US06784192B2

Reaction notes

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