関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methylamine | HCID 6329 | — |
| 反応物 | Phthalimidoamlodipine | HCID 9871958 | — |
| 生成物 | Amlodipine | HCID 2162 | — |
反応手順
Phthaloyl amlodipine (100 g, 0.18 M) was reacted with monomethyl amine (500 g, 40% solution) in denatured spirit at room temperature for 8 hrs, cooled to 0° C., filtered, washed with distilled water up to neutral pH and dried at 60-65° C. for 8 ills. Yield 58 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06784297B2 |
|---|
| 出典データセット | uspto-grants-2004_08 |
|---|
| ORD ID | ord-0446c85fbae1475e863fd016fb81c07c |
|---|
| 出典メモ | uspto-grants-2004_08 |
|---|
