反应详情

温度

0 °C

Phthaloyl amlodipine (100 g, 0.18 M) was reacted with monomethyl amine (500 g, 40% solution) in denatured spirit at room temperature for 8 hrs, cooled to 0° C., filtered, washed with distilled water up to neutral pH and dried at 60-65° C. for 8 ills. Yield 58 g.

1. filtrationfiltered
2. washwashed with distilled water up to neutral pH
3. customdried at 60-65° C. for 8 ills