2-Amino-5-chloropyridine → HCID 10139507, compound

HRID 1837822Notes

Reaction equation

HRID 1837822 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[CH:9]1([CH2:15][C@H:16]([N:20]2[C:24](=[O:25])[C@H:23]([CH2:26][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[NH:22][C:21]2=[O:33])[C:17](O)=[O:18])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:17](=[O:18])[C@@H:16]([N:20]2[C:24](=[O:25])[C@H:23]([CH2:26][CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[NH:22][C:21]2=[O:33])[CH2:15][CH:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 67483652HCID 67483652, compound

Product 1

HCID 10139507HCID 10139507, compound

Procedure

By using the conditions described in Step (iv) of Example 17, 2-amino-5-chloropyridine was condensed with (S,S)-3-cyclohexyl-2-[4-(cyclohexyl)methyl-2,5-dioxoimidazolidinyl]propanoic acid [Example 17, Step (iii)] to give the title compound as a colorless foam: EI-HRMS m/e calcd for C24H33N4O3Cl (M+) 461.2319, found 461.2321.

Sources & evidence

ORD record
ord-bdba93e2ab9f43188d923159180aeba8
Source dataset
uspto-grants-2004_08
Patent number
US06784298B2

Reaction notes

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