反应详情

A solution of 10-4 (10 g, 53.4 mmol), 2-amino-3-formylpyridine 1-3 (7.2 g, 64 mmol), 20% aq. KOH (1 mL), and ethanol (200 mL) was heated at reflux for 3 h. Evaporation of the solvents and flash chromatography (silica, 70 CHCl3/28 EtOAc/2 MeOH) gave 10-5 as a solid.

1. temperatureat reflux for 3 h
2. customEvaporation of the solvents and flash chromatography (silica, 70 CHCl3/28 EtOAc/2 MeOH)