Sodium Hydroxide → HCID 53723112, compound

HRID 1837898Notes

Reaction equation

HRID 1837898 reaction equation
C([O:3][C:4](=[O:31])[CH2:5][C@@H:6]([C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=1)[NH:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][C:14]1[CH:23]=[CH:22][C:21]2[CH2:20][CH2:19][CH2:18][NH:17][C:16]=2[N:15]=1)=[O:9])C.[OH-].[Na+]>CCO>[F:30][C:26]1[CH:25]=[C:24]([C@@H:6]([NH:7][C:8]([NH:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[CH2:20][CH2:19][CH2:18][NH:17][C:16]=3[N:15]=2)=[O:9])[CH2:5][C:4]([OH:31])=[O:3])[CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53994143HCID 53994143, compound

Product 1

HCID 53723112HCID 53723112, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 11-9 (0.4037 mmol) in EtOH (3 mL) was added 1N NaOH (0.600 ml, 0.600 mmol). After stirring for 2 h, the solvents were evaporated and the residue was chromatographed (silica gel, 20:10:1:1 to 10:10:1:1 ethyl acetate/EtOH/water/NH4OH) to give 11-10 as a white solid.

Workup

  1. customthe solvents were evaporated
  2. customthe residue was chromatographed (silica gel, 20:10:1:1 to 10:10:1:1 ethyl acetate/EtOH/water/NH4OH)

Sources & evidence

ORD record
ord-f986c0b21d6741f293c1e625a9a33b18
Source dataset
uspto-grants-2004_08
Patent number
US06784190B2

Reaction notes

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