2-bromo-5-phenylthiophene → HCID 10133330, compound

HRID 1837997Notes

Reaction equation

HRID 1837997 reaction equation
[CH:1]([C@@H:3]1[N:7]([CH3:8])[C:6](=[O:9])[CH2:5][C@@H:4]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:2].Br[C:17]1[S:18][C:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:20][CH:21]=1>>[OH:2][C@H:1]([C:17]1[S:18][C:19]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[CH:20][CH:21]=1)[C@@H:3]1[N:7]([CH3:8])[C:6](=[O:9])[CH2:5][C@@H:4]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 27763132-bromo-5-phenylthiopheneHCID 13825985(-)-(4R*,5R*)-5-formyl-1-methyl-4-phenylpyrrolidin-2-one

Product 1

HCID 10133330HCID 10133330, compound

Procedure

(4R,5R)-5-[(1S)-Hydroxy(5-phenyl(2-thienyl))methyl]-1-methyl-4-phenyl-pyrrolidin-2-one was prepared from Intermediate Z and 2-bromo-5-phenylthiophene by a method analogous to that described for Example 6, then separated using the HPLC Separation B apparatus.

Workup

  1. customseparated
  2. customthe HPLC Separation B apparatus

Sources & evidence

ORD record
ord-d08f588d3c574fa181321d7e1a7037c2
Source dataset
uspto-grants-2004_08
Patent number
US06784167B2

Reaction notes

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