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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1837997Generated: November 1, 2026

2-bromo-5-phenylthiophene → HCID 10133330, compound

https://huagongshe.com/reaction/1837997

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-bromo-5-phenylthiopheneHCID 2776313—
Reactant(-)-(4R*,5R*)-5-formyl-1-methyl-4-phenylpyrrolidin-2-oneHCID 13825985—
ProductHCID 10133330HCID 10133330—

Reaction Steps

(4R,5R)-5-[(1S)-Hydroxy(5-phenyl(2-thienyl))methyl]-1-methyl-4-phenyl-pyrrolidin-2-one was prepared from Intermediate Z and 2-bromo-5-phenylthiophene by a method analogous to that described for Example 6, then separated using the HPLC Separation B apparatus.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06784167B2
Source datasetuspto-grants-2004_08
ORD IDord-d08f588d3c574fa181321d7e1a7037c2
Source noteuspto-grants-2004_08