Potassium Carbonate → HCID 135617195, compound

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Reaction Steps

In analogy to the procedure described in example 1, the 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one (as prepared in Eur. Pat. Appl. EP 1 074 549 A2) was treated with the (2-fluoro-phenyl)-piperazine in N,N-dimethylformamide in the presence of potassium carbonate at room temperature to yield the 6-[4-(2-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one as yellow amorphous solid; MS: [M+H]+=334.

Provenance & Evidence