Potassium Carbonate → HCID 135617195, compound

HRID 1838127Notes

Reaction equation

HRID 1838127 reaction equation
Br[C:2]1[N:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[C:3]=1[N+:10]([O-:12])=[O:11].[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]1[CH2:25][CH2:24][N:23]([C:2]2[N:7]=[C:6]([CH3:8])[NH:5][C:4](=[O:9])[C:3]=2[N+:10]([O-:12])=[O:11])[CH2:22][CH2:21]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 705291-(2-Fluorophenyl)piperazineHCID 1356171936-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one

Product 1

HCID 135617195HCID 135617195, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 1, the 6-bromo-2-methyl-5-nitro-3H-pyrimidin-4-one (as prepared in Eur. Pat. Appl. EP 1 074 549 A2) was treated with the (2-fluoro-phenyl)-piperazine in N,N-dimethylformamide in the presence of potassium carbonate at room temperature to yield the 6-[4-(2-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one as yellow amorphous solid; MS: [M+H]+=334.

Sources & evidence

ORD record
ord-5455a0aaf1cb406797d42c04734469d9
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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