Potassium Iodide → HCID 18753199, compound

Participants

Reaction Steps

In analogy to the procedure described in example 8, the 6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one (example 1) was treated with 2-bromo-propane, potassium iodide and potassium carbonate in N,N-dimethylformamide at 80° C. to yield the 4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-6-isopropoxy-2-methyl-5-nitro-pyrimidine as a light yellow solid; m.p. 98-100° C.; MS: [M+H]+=376.

Provenance & Evidence