Potassium Iodide → HCID 18753199, compound

HRID 1838135Notes

Reaction equation

HRID 1838135 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[N:19]=[C:18]([CH3:20])[NH:17][C:16](=[O:21])[C:15]=3[N+:22]([O-:24])=[O:23])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Br[CH:26]([CH3:28])[CH3:27].[I-].[K+].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([C:14]3[C:15]([N+:22]([O-:24])=[O:23])=[C:16]([O:21][CH:26]([CH3:28])[CH3:27])[N:17]=[C:18]([CH3:20])[N:19]=3)[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 135617196HCID 135617196, compound

Product 1

HCID 18753199HCID 18753199, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 8, the 6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one (example 1) was treated with 2-bromo-propane, potassium iodide and potassium carbonate in N,N-dimethylformamide at 80° C. to yield the 4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-6-isopropoxy-2-methyl-5-nitro-pyrimidine as a light yellow solid; m.p. 98-100° C.; MS: [M+H]+=376.

Sources & evidence

ORD record
ord-62eb4f0e15fd4ebaa6020093cc2fc182
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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