Diisopropylethylamine → 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride	HCID 197747	—
Reactant	4-Chloro-2,6-bis[(2-hydroxyethyl)amino]pyrimidine-5-carbonitrile	HCID 18753217	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile	HCID 18753262	—

Reaction Steps

In analogy to the procedure described in example 20b, 4-chloro-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile was treated with 4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride in dioxane in the presence of N-ethyl-diisopropyl-amine at 90° C. to yield 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as an amorphous, white solid;

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06673795B2
Source dataset	uspto-grants-2004_01
ORD ID	ord-16a03bba2f75451e99cd71f41841ad4b
Source note	uspto-grants-2004_01