Cyclopropylamine → HCID 18753283, compound

HRID 1838170Notes

Reaction equation

HRID 1838170 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:10])[N:5]=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[N:3]=1.[CH:15]1([NH2:18])[CH2:17][CH2:16]1.C(N(C(C)C)C(C)C)C>O1CCOCC1>[Cl:10][C:6]1[C:7]([C:8]#[N:9])=[C:2]([NH:18][CH:15]2[CH2:17][CH2:16]2)[N:3]=[C:4]([NH:11][CH2:12][CH2:13][OH:14])[N:5]=1

Participants

5

Reactant 3

HCID 69828CyclopropylamineHCID 81531DiisopropylethylamineHCID 18753232HCID 18753232, compound

Product 1

HCID 18753283HCID 18753283, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in example 38b, 4,6-dichloro-2-(2-hydroxy-ethyl-amino)-pyrimidine-5-carbonitrile was treated with cyclopropylamine in dioxane in the presence of N-ethyl-diisopropylamine at 90° C. to yield 4-chloro-6-cyclopropylamino-2-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile as an amorphous, white solid; MS: [M+H]+=254.

Sources & evidence

ORD record
ord-455397f650e549b2b0992f2e21c9f44a
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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