HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenylpiperazine → HCID 18753268, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 18753265 | HCID 18753265 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 18753268 | HCID 18753268 | — |
Reaction Steps
In analogy to the procedure described in example 20b, 4,6-dichloro-2-(cyclopropyl-methyl-amino)-pyrimidine-5-carbonitrile was treated with 1-phenyl-piperazine in the presence of N-ethyl-diisopropylamine in dioxane at room temperature during 18 hours to yield 4-chloro-2-(cyclopropylmethyl-amino)-6-(4-phenyl-piperazin-1-yl)-pyrimidine-5-carbonitrile as an amorphous, white solid; MS: [M+H]+=369.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673795B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-4e1fc5680d4740daaa55c9f9573aacd9 |
| Source note | uspto-grants-2004_01 |