1-Phenylpiperazine → HCID 18753268, compound

HRID 1838197Notes

Reaction equation

HRID 1838197 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:10])[N:5]=[C:4]([N:11]([CH:13]2[CH2:15][CH2:14]2)C)[N:3]=1.[C:16]1([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH2:28](N(C(C)C)C(C)C)C>O1CCOCC1>[Cl:10][C:6]1[C:7]([C:8]#[N:9])=[C:2]([N:25]2[CH2:26][CH2:27][N:22]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:23][CH2:24]2)[N:3]=[C:4]([NH:11][CH2:13][CH:15]2[CH2:14][CH2:28]2)[N:5]=1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 81531DiisopropylethylamineHCID 18753265HCID 18753265, compound

Product 1

HCID 18753268HCID 18753268, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to the procedure described in example 20b, 4,6-dichloro-2-(cyclopropyl-methyl-amino)-pyrimidine-5-carbonitrile was treated with 1-phenyl-piperazine in the presence of N-ethyl-diisopropylamine in dioxane at room temperature during 18 hours to yield 4-chloro-2-(cyclopropylmethyl-amino)-6-(4-phenyl-piperazin-1-yl)-pyrimidine-5-carbonitrile as an amorphous, white solid; MS: [M+H]+=369.

Sources & evidence

ORD record
ord-4e1fc5680d4740daaa55c9f9573aacd9
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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