Diisopropylethylamine → 2-Amino-4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-6-methylsulfanyl-pyrimidine-5-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2-Amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile	HCID 18753230	—
Reactant	4-(4-Fluoro-phenyl)-piperidine hydrochloride	HCID 21898168	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	2-Amino-4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-6-methylsulfanyl-pyrimidine-5-carbonitrile	HCID 18753253	—

Reaction Steps

In analogy to the procedure described in example 20b, the 2-amino-4-bromo-6-methylsulfanyl-pyrimidine-5-carbonitrile (see example 69) was treated with the 4-(4-fluorophenyl)-piperidine hydrochloride in dioxane in the presence of N-ethyl-diiso-propylamine at room temperature during 36 hours to yield 2-amino-4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-6-methylsulfanyl-pyrimidine-5-carbonitrile as a yellow solid; MS: [M+H]+=344.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06673795B2
Source dataset	uspto-grants-2004_01
ORD ID	ord-5b23574fe19f4d9aa9963a426cae49b6
Source note	uspto-grants-2004_01