Ethanolamine → HCID 18753292, compound

HRID 1838215Notes

Reaction equation

HRID 1838215 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]([C:21]#[N:22])=[C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[N:8]=1.[CH2:23]([CH2:25][NH2:26])[OH:24]>>[OH:24][CH2:23][CH2:25][NH:26][C:3]1[N:4]=[N:5][C:6]([C:21]#[N:22])=[C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[N:8]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 18753275HCID 18753275, compound

Product 1

HCID 18753292HCID 18753292, compound

Procedure

In analogy to the procedure described in example 84c, 3-methylsulfanyl-5-(4-phenyl-piperazin-1-yl)-[1,2,4]triazine-6-carbonitrile was treated with ethanolamine in a sealed tube at 140° C. during 18 hours to yield 3-(2-hydroxy-ethylamino)-5-(4-phenyl-piperazin-1-yl)-[1,2,4]triazine-6-carbonitrile as an amorphous, white solid; MS: [M+H]+=326.

Sources & evidence

ORD record
ord-bf7a91c543464f4d92588f5358f2426b
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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