Ethanolamine → HCID 18753292, compound

Participants

Reaction Steps

In analogy to the procedure described in example 84c, 3-methylsulfanyl-5-(4-phenyl-piperazin-1-yl)-[1,2,4]triazine-6-carbonitrile was treated with ethanolamine in a sealed tube at 140° C. during 18 hours to yield 3-(2-hydroxy-ethylamino)-5-(4-phenyl-piperazin-1-yl)-[1,2,4]triazine-6-carbonitrile as an amorphous, white solid; MS: [M+H]+=326.

Provenance & Evidence