N-BOC-ethylenediamine → HCID 69034531, compound

HRID 1838216Notes

Reaction equation

HRID 1838216 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]([C:21]#[N:22])=[C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[N:8]=1.[C:23]([NH:30][CH2:31][CH2:32][NH2:33])([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>>[C:26]([O:25][C:23](=[O:24])[NH:30][CH2:31][CH2:32][NH:33][C:3]1[N:4]=[N:5][C:6]([C:21]#[N:22])=[C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)[N:8]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 18753275HCID 18753275, compound

Product 1

HCID 69034531HCID 69034531, compound

Procedure

In analogy to the procedure described in example 84c, 3-methylsulfanyl-5-(4-phenyl-piperazin-1-yl)-[1,2,4]triazine-6-carbonitrile was treated with N-Boc-ethylene-diamine in a sealed tube at 130° C. during 48 hours to yield {2-[6-cyano-5-(4-phenyl-piperazin-1-yl)-[1,2,4]triazin-3-ylamino]-ethyl}-carbamic acid tert-butyl ester as an amorphous, light yellow solid; MS: [M+H]+=425.

Sources & evidence

ORD record
ord-30d9a177b301465f8ae9ae77342fb6f3
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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