Hydrochloric Acid → HCID 15521781, compound

HRID 1838224Notes

Reaction equation

HRID 1838224 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[O:20][CH3:21])[C:6](=[O:22])[C:5]2([C:24]1[CH:29]=[C:28]([CH2:30][O:31]COC)[CH:27]=[CH:26][C:25]=1[Cl:35])[OH:23].CO.Cl>ClCCl.O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1[O:20][CH3:21])[C:6](=[O:22])[C:5]2([C:24]1[CH:29]=[C:28]([CH2:30][OH:31])[CH:27]=[CH:26][C:25]=1[Cl:35])[OH:23]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15521761HCID 15521761, compound

Product 1

HCID 15521781HCID 15521781, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

A mixture of 0:307 g of the compound of Example 19, 15 ml of methanol and 1 ml of 10N hydrochloric acid is heated at 50° C. for 2 hours. The solvent is evaporated under reduced pressure and the residue obtained is taken up in dichloromethane and water. The organic phase is washed twice with water and then dried over anhydrous sodium sulphate. The solvents are evaporated under reduced pressure. The expected product is isolated after solidifying in cyclohexane, filtering and drying at 30° C. under reduced pressure for 6 hours; M.p.=107° C.

Workup

  1. additionA mixture of 0
  2. customThe solvent is evaporated under reduced pressure
  3. customthe residue obtained
  4. washThe organic phase is washed twice with water
  5. dry with materialdried over anhydrous sodium sulphate
  6. customThe solvents are evaporated under reduced pressure

Sources & evidence

ORD record
ord-217ecb2f2f9043e3ab537d5b8c701a93
Source dataset
uspto-grants-2004_01
Patent number
US06673790B1

Reaction notes

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