HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → 1-Cbz-3-Methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | 2-Methylpiperazine | HCID 66057 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Cbz-3-Methylpiperazine | HCID 10421542 | — |
Reaction Steps
A 4 g portion of 2-methylpiperazine was dissolved in 40 ml of dichloromethane, and 1.71 g of benzyl chloroformate was added dropwise thereto at −78° C. After 1 hour of stirring, the mixture was washed by adding water and dried and then the solvent was evaporated to obtain 2.0 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673799B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-3975fcf26ad248c2b8742c9b0e87636a |
| Source note | uspto-grants-2004_01 |