Benzyl chloroformate → 1-Cbz-3-Methylpiperazine

HRID 1838237Notes

Reaction equation

HRID 1838237 reaction equation
[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.Cl[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10]>ClCCl>[CH3:1][CH:2]1[NH:3][CH2:4][CH2:5][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:7]1

Participants

4

Reactant 2

HCID 10387Benzyl chloroformateHCID 660572-Methylpiperazine

Product 1

HCID 104215421-Cbz-3-Methylpiperazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A 4 g portion of 2-methylpiperazine was dissolved in 40 ml of dichloromethane, and 1.71 g of benzyl chloroformate was added dropwise thereto at −78° C. After 1 hour of stirring, the mixture was washed by adding water and dried and then the solvent was evaporated to obtain 2.0 g of the title compound.

Workup

  1. customat −78° C
  2. washthe mixture was washed
  3. additionby adding water
  4. customdried
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-3975fcf26ad248c2b8742c9b0e87636a
Source dataset
uspto-grants-2004_01
Patent number
US06673799B1

Reaction notes

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