4-Fluoroaniline → trans-4-(4-Cyano-3-trifluoromethylphenyl)-N-(4-fluorophenyl)-2,5-dimethylpiperazine-1-sulfonamide

Participants

Reaction Steps

A 1.21 g portion of trans-4-(2,5-dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile synthesized in Reference Example 1-1 and 2.05 g of sulfamide were heated under reflux for 1.5 hours in 15 ml of pyridine. Next, this was mixed with 4.05 ml of 4-fluoroaniline and again heated under reflux for 4 hours. After evaporation of the solvent, the residue was purified by a silica gel column chromatography to obtain 701 mg of the title compound from toluene-ethyl acetate eluate.

Provenance & Evidence