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HRID1838258

反应详情

EQUATION

反应方程式

HRID 1838258 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccc(F)cc1
HCID9731

4-Fluoroaniline

C6H6FN

结构：NS(N)(=O)=O
HCID82267

Sulfamide

H4N2O2S

结构：C[C@@H]1CN(c2ccc(C#N)c(C(F)(F)F)c2)[C@@H](C)CN1
HCID11391932

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1CN(S(=O)(=O)Nc2ccc(F)cc2)[C@@H](C)CN1c1ccc(C#N)c(C(F)(F)F)c1
HCID69108864

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A 1.21 g portion of trans-4-(2,5-dimethylpiperazin-1-yl)-2-trifluoromethylbenzonitrile synthesized in Reference Example 1-1 and 2.05 g of sulfamide were heated under reflux for 1.5 hours in 15 ml of pyridine. Next, this was mixed with 4.05 ml of 4-fluoroaniline and again heated under reflux for 4 hours. After evaporation of the solvent, the residue was purified by a silica gel column chromatography to obtain 701 mg of the title compound from toluene-ethyl acetate eluate.

WORKUP

后处理

  1. temperaturewere heated
  2. temperatureagain heated
  3. temperatureunder reflux for 4 hours
  4. customAfter evaporation of the solvent
  5. customthe residue was purified by a silica gel column chromatography