Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-(5-methyl-3-nitro-pyridin-2-yl)-acrylic acid ethyl ester

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Reaktionsgleichung

CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].[CH2:9]([O:11][C:12](=[O:24])[CH2:13][C:14]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][C:17]([CH3:23])=[CH:16][N:15]=1)[CH3:10]>CN(C=O)C>[CH2:9]([O:11][C:12](=[O:24])[C:13]([C:14]1[C:19]([N+:20]([O-:22])=[O:21])=[CH:18][C:17]([CH3:23])=[CH:16][N:15]=1)=[CH:3][N:4]([CH3:5])[CH3:6])[CH3:10]

Komponenten

Reaktionsbedingungen

Temperatur: 60 °C

Versuchsvorschrift

A solution of dimethylformamide dimethyl acetal (4 g, 0.033 mol) in dry DMF (10 mL) is added to a solution of (5-methyl-3-nitro-pyridin-2yl)-acetic acid ethyl ester (5 g, 0.022 mol) in dry DMF (20 mL) to give a red solution. This solution is heated at 60° C. under reduced pressure for 3 h. DMF and other volatile components are evaporated under reduced pressure to obtain 3-dimethylamino-2-(5-methyl-3-nitro-pyridin-2-yl)-acrylic acid ethyl ester as an viscous oil which was used without further purification.

Aufarbeitung

customto give a red solution
customDMF and other volatile components are evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-779b6587706d4ec280bc21208c900b9e
Quelldatensatz: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06673811B1

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