Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-(5-methyl-3-nitro-pyridin-2-yl)-acrylic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

A solution of dimethylformamide dimethyl acetal (4 g, 0.033 mol) in dry DMF (10 mL) is added to a solution of (5-methyl-3-nitro-pyridin-2yl)-acetic acid ethyl ester (5 g, 0.022 mol) in dry DMF (20 mL) to give a red solution. This solution is heated at 60° C. under reduced pressure for 3 h. DMF and other volatile components are evaporated under reduced pressure to obtain 3-dimethylamino-2-(5-methyl-3-nitro-pyridin-2-yl)-acrylic acid ethyl ester as an viscous oil which was used without further purification.

Provenance & Evidence