Hydrochloric Acid → HCID 12094551, compound

HRID 1838350Notes

Reaction equation

HRID 1838350 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[N:13]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[C:14]3[C:19]([CH:20]=2)=[CH:18][C:17]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:16][CH:15]=3)=[N:10][CH:11]=1)=[O:5])C.[OH-].[K+].CO.Cl>O>[F:32][C:29]1[CH:28]=[CH:27][C:26]([CH2:25][N:13]2[C:14]3[C:19](=[CH:18][C:17]([S:21]([CH3:24])(=[O:22])=[O:23])=[CH:16][CH:15]=3)[CH:20]=[C:12]2[C:9]2[CH:8]=[CH:7][C:6]([C:4]([O:3][CH3:1])=[O:5])=[CH:11][N:10]=2)=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 22504405HCID 22504405, compound

Product 1

HCID 12094551HCID 12094551, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
22.5 °C

Procedure

A mixture of 2-(5-ethoxycarbonylpyridin-2-yl)-1-(4-fluorobenzyl)-5-methanesulfonylindole (0.68 g), potassium hydroxide (0.24 g) and methanol (45 ml) was stirred at 15 to 30° C. for 30 minutes under nitrogen atmosphere. To the reaction solution was added water and the mixture was neutralized with hydrochloric acid. The precipitated crystal was filtered off. The resulting crude crystal was recrystallized (methanol) to obtain 0.44 g of the desired. product.

Workup

  1. filtrationThe precipitated crystal was filtered off
  2. customThe resulting crude crystal was recrystallized (methanol)
  3. customto obtain 0.44 g of the

Sources & evidence

ORD record
ord-8b466f9745314b4eac5b0323e6653d2f
Source dataset
uspto-grants-2004_01
Patent number
US06673797B1

Reaction notes

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