HRID1838414

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1263495

ST093135

C13H14N2O3

HCID12042107

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H](CCO)C(=O)OCc1ccccc1

HCID13970788

未命名化合物

PRODUCTS

生成物

HCID6809

Phthalimide

C8H5NO2

结构：Cc1cn(COCc2ccccc2)c(=O)n(CCC(NC(=O)OC(C)(C)C)C(=O)OCc2ccccc2)c1=O

HCID18753565

未命名化合物

收率 51%

PROCEDURE

实验过程

In a similar manner to that described in Example 1(1), a reaction was carried out using (±)-N-(tert-butoxycarbonyl)homoserine benzyl ester, instead of (±)-N-(tert-butoxycarbonyl)homoserine allyl ester, and using 1-benzyloxymethyl-5-methyl-pyrimidine-2,4-dione, instead of phthalimide, to afford the desired compound (yield 51%) as a white powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a6ef19a71f224800b3aed5db7800b51e
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06673804B1
来源说明: uspto-grants-2004_01

反应 SMILES

[CH2:1]([O:8][C:9](=[O:22])[C@H:10]([CH2:19][CH2:20]O)[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(=O)[C@H](CCO)[NH:29][C:30](OC(C)(C)C)=[O:31])C=C.[CH2:41]([O:48][CH2:49][N:50]1[CH:55]=[C:54]([CH3:56])[C:53](=[O:57])[NH:52][C:51]1=[O:58])[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[C:30]1(=[O:31])[NH:29][C:1](=[O:8])[C:2]2=[CH:3][CH:4]=[CH:5][CH:6]=[C:7]12.[CH2:1]([O:8][C:9](=[O:22])[CH:10]([CH2:19][CH2:20][N:52]1[C:53](=[O:57])[C:54]([CH3:56])=[CH:55][N:50]([CH2:49][O:48][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C:51]1=[O:58])[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1