Uracil → Benzyl chloromethyl ether

HRID 1838433Notes

Reaction equation

N1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])NC1=O.N1C=CC(=O)NC1=O.C[Si](C)(C)CCO[CH2:26][Cl:27]>>[CH2:4]([O:11][CH2:26][Cl:27])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

Reactant 3

HCID 1174Uracil

HCID 64048Quinazolinedione

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using quinazoline-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 87%) as a white powder.

Sources & evidence

ORD record: ord-fa2eee8ac91c4126975f211a7b476317
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06673804B1

Reaction notes

Loading…