Uracil → Benzyl chloromethyl ether

HRID 1838437Notes

Reaction equation

HRID 1838437 reaction equation
N1[C:10]2[C:5](=NC=CN=2)[C:4](=O)NC1=O.N1C=[CH:17][C:16](=O)NC1=O.C[Si](C)(C)[CH2:23][CH2:24][O:25][CH2:26][Cl:27]>>[CH2:24]([O:25][CH2:26][Cl:27])[C:23]1[CH:4]=[CH:5][CH:10]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 1174UracilHCID 10250LumazineHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using pteridin-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 53%) as a yellow powder.

Sources & evidence

ORD record
ord-85db933605be4fb6a518977183ca41e0
Source dataset
uspto-grants-2004_01
Patent number
US06673804B1

Reaction notes

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