Uracil → Benzyl chloromethyl ether

HRID 1838438Notes

Reaction equation

HRID 1838438 reaction equation
[CH3:1][C:2]1NC(=O)N[C:4](=[O:9])[CH:3]=1.N1[CH:15]=[CH:14][C:13](=O)NC1=O.C[Si](C)(C)CCO[CH2:23][Cl:24]>>[CH2:4]([O:9][CH2:23][Cl:24])[C:3]1[CH:2]=[CH:1][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 1174UracilHCID 122836-MethyluracilHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 6-methylpyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 56%) as a white powder.

Sources & evidence

ORD record
ord-0c30c2726c5c41889670920921fb95ef
Source dataset
uspto-grants-2004_01
Patent number
US06673804B1

Reaction notes

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