Uracil → Benzyl chloromethyl ether

HRID 1838442Notes

Reaction equation

HRID 1838442 reaction equation
Cl[C:2]1NC(=O)N[C:4](=O)[CH:3]=1.N1C=[CH:14][C:13](=O)NC1=O.C[Si](C)(C)[CH2:20][CH2:21][O:22][CH2:23][Cl:24]>>[CH2:21]([O:22][CH2:23][Cl:24])[C:20]1[CH:14]=[CH:13][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 1174UracilHCID 732726-ChlorouracilHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl ether

Product 1

HCID 137983Benzyl chloromethyl ether

Procedure

In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 6-chloropyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 71%) as a white powder.

Sources & evidence

ORD record
ord-a12ae5c03b6341faa67cb8baba1ba41a
Source dataset
uspto-grants-2004_01
Patent number
US06673804B1

Reaction notes

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