Fumaric Acid → 90471-79-7

HRID 1838486Notes

Reaction equation

HRID 1838486 reaction equation
CC([O:4][C@@H:5]([CH2:10][N+:11]([CH3:14])([CH3:13])[CH3:12])[CH2:6][C:7]([O-:9])=[O:8])=O.[C:15]([OH:22])(=[O:21])/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19]>C(O)C>[CH3:12][N+:11]([CH2:10][C@H:5]([OH:4])[CH2:6][C:7]([OH:9])=[O:8])([CH3:13])[CH3:14].[CH:16](/[C:15]([O-:22])=[O:21])=[CH:17]\[C:18]([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 7045767Acetyl-L-carnitine

Product 1

HCID 7165619690471-79-7

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 10 mL of 95% v/v of ethanol at about 70° C., 2.28 g (0.01 moles) of acetyl L-carnitine inner salt (titre: 89.3%) and 1.16 g (0.01 moles) of fumaric acid were added under vigorous stirring. The resulting solution (“mother solution”) was cooled to room temperature while constantly keeping it under stirring. To the solution, a few milligrams of L-carnitine acid fumarate as precipitating agent were added. In few minutes a white, heavy precipitate formed which was filtered off one hour later.

Workup

  1. customTo the solution, a few milligrams of L-carnitine acid fumarate as precipitating agent
  2. additionwere added
  3. customIn few minutes a white, heavy precipitate formed which
  4. filtrationwas filtered off one hour later

Sources & evidence

ORD record
ord-8dad1b0dae094a6f8b45d5642a05873e
Source dataset
uspto-grants-2004_01
Patent number
US06673837B2

Reaction notes

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