反应详情

3-Bromo-1-propanol (584 mg, 4.2 mmol) was added to a mixture of (S)-pyrrolidine-2-carboxamide (399 mg, 3.5 mmol) and potassium carbonate (966 mg, 7 mmol) in acetonitrile (10 ml). The mixture was heated at reflux for 5 hours and the mixture was stirred for 18 hours at ambient temperature. The insolubles were removed by filtration and the solvent was removed from the filtrate by evaporation. The residue was purified by column chromatography on silica eluting with methylene chloride/methanol (9/1 followed by 8/2) to give (S)-1-(3-hydroxypropyl)-pyrrolidine-2-carboxamide (365 mg, 60%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 5 hours
3. customThe insolubles were removed by filtration
4. customthe solvent was removed from the filtrate by evaporation
5. customThe residue was purified by column chromatography on silica eluting with methylene chloride/methanol (9/1 followed by 8/2)