2-Methoxybenzaldehyde → HCID 12116618, compound

HRID 1838655Notes

Reaction equation

HRID 1838655 reaction equation
[CH:1](=[O:10])[C:2]1[C:3]([O:8][CH3:9])=[CH:4][CH:5]=[CH:6][CH:7]=1.[S:11]([CH2:21][N+:22]#[C-:23])([C:14]1[CH:20]=[CH:19][C:17]([CH3:18])=[CH:16][CH:15]=1)(=[O:13])=[O:12].[C-]#N.[Na+]>>[CH3:9][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C@H:1]1[O:10][CH:23]=[N:22][C@@H:21]1[S:11]([C:14]1[CH:20]=[CH:19][C:17]([CH3:18])=[CH:16][CH:15]=1)(=[O:13])=[O:12]

Participants

4

Reactant 3

HCID 86582-MethoxybenzaldehydeHCID 8929Sodium CyanideHCID 161915Tosylmethyl isocyanide

Product 1

HCID 12116618HCID 12116618, compound

Procedure

In a manner analogous to Preparation 1, 0-anisaldehyde (053 mL, 5.25 mmol), tosylmethylisocyanide (0.98 g, 5.0 mmol) and NaCN (24.5 mg, 0.50 mmol) gave the desired compound as a tan solid. MS(ES+) m/z 332.0 (M+H+).

Sources & evidence

ORD record
ord-8070bf111a894530aa07ef192c5fc4f7
Source dataset
uspto-grants-2004_01
Patent number
US06673941B2

Reaction notes

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