Hydrochloric Acid → HCID 69894511, compound

Participants

Reaction Steps

0.2 g of 1,5-bis-{2-[4-(4-tert-butyloxycarbonylaminomethylbenzylaminocarbonyl)piperazin-1-yl]-2-oxoethyl}-perhydro-1,5-diazocin-2,6-dione (starting material A1) is suspended in 2 ml of dichloromethane and then admixed with 2 ml of trifluoroacetic acid. The mixture is stirred at RT overnight, and 2 ml of a solution of HCl in dioxane are then added. The mixture is concentrated to dryness using a rotary evaporator. The residue is twice triturated with ether and the solvent decanted off. The residue is then dried under high vacuum. This gives 0.17 g of the title compound of m.p. from 90° C. (decomposition). The mass spectrum shows the molecular peak MH+ at 719 Da.

Provenance & Evidence