HCID 18752836, compound → HCID 18752844, compound

HRID 1838763Notes

Reaction equation

HRID 1838763 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:35])[CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([CH2:26][NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])=[CH:22][CH:21]=2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1>CO>[C:31]([O:30][C:28]([NH:27][CH2:26][C:23]1[CH:24]=[CH:25][C:20]([CH2:19][CH2:18][C:17]([N:14]2[CH2:13][CH2:12][NH:11][CH2:16][CH2:15]2)=[O:35])=[CH:21][CH:22]=1)=[O:29])([CH3:34])([CH3:32])[CH3:33]

Participants

3

Reactant 1

HCID 18752836HCID 18752836, compound2×

Product 1

HCID 18752844HCID 18752844, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3.64 g of 1-benzyloxycarbonyl-4-[3-(4-tert-butyloxycarbonylaminomethylphenyl)propionyl]piperazine (starting material B3), dissolved in 100 ml methanol are hydrogenated over palladiumicarbon (10%) for 3 h. The catalyst is filtered off and the solvent is removed in vacuo, giving 2.55 g of the title compound. The mass spectrum shows the molecular peak MH+ at 348 Da.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-fab7704490664be8a9b8d88aad66816b
Source dataset
uspto-grants-2004_01
Patent number
US06673786B1

Reaction notes

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