HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-[[4-(Boc-amino)methyl]phenoxy]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 18752843 | HCID 18752843 | — |
| Reactant | 3-(3-{[(tert-Butoxycarbonyl)amino]methyl}phenyl)propanoic acid | HCID 22282728 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[[4-(Boc-amino)methyl]phenoxy]acetic acid | HCID 18752838 | — |
Reaction Steps
1 g of methyl 2-(4-tert-butoxycarbonylaminomethyl-phenoxy)acetate (starting material D3) is saponified with 4.1 ml 1N aqueous sodium hydroxide solution in 10 ml tetrahydrofurane as described for starting material C2. Yield: 0.7g; the mass spectrum shows the molecular peak MNa+ at 304 Da.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06673786B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-f850fcff489d45a3bb62f2dbec3cd631 |
| Source note | uspto-grants-2004_01 |