Sodium Hydroxide → 2-[[4-(Boc-amino)methyl]phenoxy]acetic acid

HRID 1838767Notes

Reaction equation

HRID 1838767 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:21]=[CH:20][C:13]([O:14][CH2:15][C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].C(OC(NCC1C=C(CCC(O)=O)C=CC=1)=O)(C)(C)C>O1CCCC1>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:20][CH:21]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 18752843HCID 18752843, compound2×HCID 222827283-(3-{[(tert-Butoxycarbonyl)amino]methyl}phenyl)propanoic acid

Product 1

HCID 187528382-[[4-(Boc-amino)methyl]phenoxy]acetic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1 g of methyl 2-(4-tert-butoxycarbonylaminomethyl-phenoxy)acetate (starting material D3) is saponified with 4.1 ml 1N aqueous sodium hydroxide solution in 10 ml tetrahydrofurane as described for starting material C2. Yield: 0.7g; the mass spectrum shows the molecular peak MNa+ at 304 Da.

Sources & evidence

ORD record
ord-f850fcff489d45a3bb62f2dbec3cd631
Source dataset
uspto-grants-2004_01
Patent number
US06673786B1

Reaction notes

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