Trifluoroacetic acid → HCID 22639309, compound

HRID 1838789Notes

Reaction equation

HRID 1838789 reaction equation
C([O:5][C:6](=[O:30])[CH2:7][O:8][CH2:9][CH:10]([O:21][C:22](=O)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:11][O:12][C:13](=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[CH2:22]([O:21][CH:10]([CH2:11][O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH2:9][O:8][CH2:7][C:6]([OH:30])=[O:5])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23448452HCID 23448452, compound

Product 1

HCID 22639309HCID 22639309, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

130 g (336.4 mmol) of the title compound of Example 7a is dissolved in 200 ml of dichloromethane, and 100 ml of trifluoroacetic acid is added at 0° C. It is stirred for 4 hours at room temperature and then evaporated to the dry state. The residue is crystallized from pentane/diethyl ether.

Workup

  1. customevaporated to the dry state
  2. customThe residue is crystallized from pentane/diethyl ether

Sources & evidence

ORD record
ord-c10862b6edb34f9c91aeee6200e68142
Source dataset
uspto-grants-2004_01
Patent number
US06676928B2

Reaction notes

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