2,6-Lutidine → L-Lysine

Participants

Reaction Conditions

Reaction Steps

250 mg (1.19 mmol) of poly-D/L-lysine hydrobromide (SIGMA; M: 30,000-70,000) are suspended in 4 ml of dimethylformamide under argon. The suspension is cooled down to 0° C. and 1.25 ml of 2,6-lutidine are added. A solution of 500 mg (2.93 mmol) of chloroacetic anhydride in 2 ml of dimethylformamide is added dropwise over the space of 15 min. The mixture is subsequently heated slowly to room temperature and stirred for 16 h. The working-up and purification take place in analogy with N(6)-chloroacetyl-poly-L-lysine. 210 mg (85%) of N(6)-chloroacetyl-poly-D/L-lysine B3 are obtained.

Provenance & Evidence