Ethanol → HCID 131724289, compound

HRID 1838803Notes

Reaction equation

HRID 1838803 reaction equation
CO[C:3]1[CH:8]=[CH:7][C:6]([O:9][CH2:10][CH:11]2[O:13][CH2:12]2)=[CH:5][CH:4]=1.[C:14]([NH:21][CH2:22][CH2:23][NH2:24])([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15].C[CH2:26][OH:27]>>[C:17]([O:16][C:14]([NH:21][CH2:22][CH2:23][NH:24][CH2:12][CH:11]([OH:13])[CH2:10][O:9][C:6]1[CH:5]=[CH:4][CH:3]=[CH:8][C:7]=1[O:27][CH3:26])=[O:15])([CH3:18])([CH3:19])[CH3:20]

Participants

4

Reactant 3

HCID 702EthanolHCID 166462,3-Epoxypropyl 4'-methoxyphenyl etherHCID 187201N-BOC-ethylenediamine

Product 1

HCID 131724289HCID 131724289, compound

Procedure

Epoxide 6 (1.0 g, 5.5 mmol) and Boc-ethylenediamine (0.88 g, 5.5 mmol) were dissolved in 20 mL EtOH and the mixture was heated at reflux for 24 h. The solvent was evaporated and the residue was purified using column chromatography (1:1, Hex:EtOAc) to afford compound 11.

Workup

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 24 h
  3. customThe solvent was evaporated
  4. customthe residue was purified

Sources & evidence

ORD record
ord-c9e9228e5bcb49dfa28f3b7fb5d9b6f0
Source dataset
uspto-grants-2004_01
Patent number
US06677336B2

Reaction notes

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