huagongshe.com
HRID1838880

反应详情

EQUATION

反应方程式

HRID 1838880 的结构方程式

REACTANTS

反应物

2
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：CC(C)(C)[Si](C)(C)OCCCCC[C@@H]1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC(=O)[C@@]1(C)C[C@@H]2F
HCID15870660

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12C[C@H](F)[C@H]3[C@@H]([C@H](CCCCCO)CC4=CC(=O)CC[C@@H]43)[C@@H]1CCC2=O
HCID15870661

未命名化合物

收率 115.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O
溶剂HCID962

Water

H2O

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A solution of 23.1 g of 11β-fluoro-7α-(5-tert-butyl-dimethylsilyloxypentyl)oestr-4-ene-3,17-dione in 115 ml of THF and 64 ml of water are stirred at 50° C. for 2.5 h with 128 ml of glacial acetic acid. The reaction mixture is concentrated in vacuo, taken up in ethyl acetate, and the solution is washed with water and dried. 20.4 g of 11β-fluoro-7α-(5-hydroxypentyl)oestr-4-ene-3,17-dione are obtained as a foam.

WORKUP

后处理

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. washthe solution is washed with water
  3. customdried