Potassium Carbonate → 11beta-Fluoro-7alpha-(5-hydroxypentyl)-3-(tetrahydro-pyran-2-yloxy)oestra-1,3,5(10)-trien-17-one

Participants

Reaction Steps

7.4 g of 7α- (5-acetoxypentyl)-11β-fluoro-3-(tetrahydro-pyran-2-yloxy)oestra-1,3,5(10)-trien-17-one are stirred with 1.8 g of potassium carbonate at room temperature in 370 ml of methanol and 37 ml of water. After 3 h, the reaction mixture is added to ice-water. The precipitated product is filtered off with suction, dissolved in ethyl acetate, and the solution is washed with water until neutral, dried and concentrated in vacuo. 7.0 g of 11β-fluoro-7α-(5-hydroxypentyl)-3-(tetrahydropyran-2-yloxy)oestra-1,3,5(10)-trien-17-one are obtained as a foam.

Provenance & Evidence