huagongshe.com
HRID1838884

反应详情

EQUATION

反应方程式

HRID 1838884 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CC(=O)OCCCCC[C@@H]1Cc2cc(OC3CCCCO3)ccc2[C@@H]2[C@@H]1[C@@H]1CCC(=O)[C@@]1(C)C[C@@H]2F
HCID22941806

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12C[C@H](F)[C@@H]3c4ccc(OC5CCCCO5)cc4C[C@@H](CCCCCO)[C@H]3[C@@H]1CCC2=O
HCID22941780

未命名化合物

收率 103.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

7.4 g of 7α- (5-acetoxypentyl)-11β-fluoro-3-(tetrahydro-pyran-2-yloxy)oestra-1,3,5(10)-trien-17-one are stirred with 1.8 g of potassium carbonate at room temperature in 370 ml of methanol and 37 ml of water. After 3 h, the reaction mixture is added to ice-water. The precipitated product is filtered off with suction, dissolved in ethyl acetate, and the solution is washed with water until neutral, dried and concentrated in vacuo. 7.0 g of 11β-fluoro-7α-(5-hydroxypentyl)-3-(tetrahydropyran-2-yloxy)oestra-1,3,5(10)-trien-17-one are obtained as a foam.

WORKUP

后处理

  1. filtrationThe precipitated product is filtered off with suction
  2. dissolutiondissolved in ethyl acetate
  3. washthe solution is washed with water until neutral,
  4. customdried
  5. concentrationconcentrated in vacuo