Sodium Chloride → HCID 54129137, compound

HRID 1838966Notes

Reaction equation

HRID 1838966 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH:9]=[O:10])=[C:4]([Cl:11])[N:3]=1.C(N(CC)CC)C.[CH3:19][O:20][C:21]1[CH:37]=[CH:36][C:24]([CH2:25][NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)=[CH:23][CH:22]=1.[Cl-].[Na+]>C(Cl)Cl>[NH2:1][C:2]1[N:3]=[C:4]([Cl:11])[C:5]([CH:9]=[O:10])=[C:6]([N:26]([CH2:25][C:24]2[CH:23]=[CH:22][C:21]([O:20][CH3:19])=[CH:37][CH:36]=2)[CH2:27][C:28]2[CH:29]=[CH:30][C:31]([O:34][CH3:35])=[CH:32][CH:33]=2)[N:7]=1

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 2655462-Amino-4,6-dichloropyrimidine-5-carboxaldehydeHCID 714952Bis(4-methoxybenzyl)amine

Product 1

HCID 54129137HCID 54129137, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2-Amino-4,6-dichloro-5-pyrimidine carbaldehyde (0.50 g; 2.60 mmol) was stirred in dry DCM (5 ml). Triethylamine (0.263 g; 2.60 mmol) and di(4-methoxybenzyl)amine (0.669 g; 2.60 mmol) were added and the reaction stirred at r.t for 1.25 h. the reaction was worked up by addition of further DCM (50 ml) and extraction with saturated sodium chloride solution (3×50 ml). The organic layer was washed with water (50 ml), dried (MgSO4) and evaporated yielding a yellow foam (0.957 g; 2.32 mmol; 89.2%).

Workup

  1. washThe organic layer was washed with water (50 ml)
  2. dry with materialdried (MgSO4)
  3. customevaporated
  4. customyielding a yellow foam (0.957 g; 2.32 mmol; 89.2%)

Sources & evidence

ORD record
ord-1e01cedddcd84612b3843e8c287ea277
Source dataset
uspto-grants-2004_01
Patent number
US06677345B1

Reaction notes

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