HCID 22347442, compound → HCID 9907963, compound

HRID 1838985Notes

Reaction equation

HRID 1838985 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[C:11]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])=O)(C)(C)C.[Cl:21][C:22]1[CH:23]=[C:24]([NH:38][C:39](OC2C=CC=CC=2)=[O:40])[C:25](=[CH:36][CH:37]=1)[C:26](OCC1C=CC=CC=1)=[O:27]>>[NH2:8][C:9]1[CH:10]=[C:11]([S:17]([N:20]2[C:26](=[O:27])[C:25]3[C:24](=[CH:23][C:22]([Cl:21])=[CH:37][CH:36]=3)[NH:38][C:39]2=[O:40])(=[O:18])=[O:19])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

3

Reactant 2

HCID 22347442HCID 22347442, compoundHCID 22347460HCID 22347460, compound

Product 1

HCID 9907963HCID 9907963, compoundYield 16%

Procedure

400 mg (1.40 mmol) of 3-t-butoxycarbonylamino-4-methoxybenzenesulfonamide and 533 mg (1.40 mmol) of benzyl 4-chloro-2-N-phenoxycarbonylanthranilate were treated in the same way as in Preparation Example 17 to obtain 86 mg (yield 16%: 4 steps) of the above-identified compound. Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δ ppm, DMSO-d6): 3.81 (3H, s), 7.26-7.37 (5H, m), 7.77 (1H, s), 7.90 (1H, d), 7.94 (1H, d), 11.73 (1H, s).

Workup

  1. customto obtain 86 mg (yield 16%: 4 steps) of the above-identified compound

Sources & evidence

ORD record
ord-aa81a87e62e0464289389d84e59276e2
Source dataset
uspto-grants-2004_01
Patent number
US06677344B2

Reaction notes

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