反应详情

Using the general method of Example 242, 1-(3-aminopropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.53 g, 5.11 mmol) was reacted with p-toluenesulfonyl chloride (1.07 g, 5.62 mmol) to provide 750 mg of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-4-methylbenzenesulfonamide as a solid, m.p. 189-191° C. Analysis: Calculated for C23H27N5O3S.0.50 H2O: %C, 59.72; %H, 6.10; %N, 15.14; Found: %C, 59.73; %H, 5.95; %N, 15.08.