Phenethyl bromide → HCID 21904372, compound

HRID 1839234Notes

Reaction equation

HRID 1839234 reaction equation
[C:1]([CH:11]([CH:27]1[NH:32][CH2:31][CH2:30][NH:29][CH2:28]1)[N:12]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:26])[C:13]([CH:15]1[CH2:18][CH2:17][CH2:16]1)=[O:14])(OCC1C=CC=CC=1)=O.C(Br)[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.C([O-])([O-])=O.[K+].[K+]>CO.CC#N.[Pd]>[CH2:1]([CH:11]([CH:27]1[NH:32][CH2:31][CH2:30][NH:29][CH2:28]1)[N:12]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:26])[C:13]([CH:15]1[CH2:18][CH2:17][CH2:16]1)=[O:14])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

7

Reactant 3

HCID 7666Phenethyl bromideHCID 11430Potassium CarbonateHCID 21904434HCID 21904434, compound

Product 1

HCID 21904372HCID 21904372, compoundYield 43%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 6342AcetonitrileSolvent

Procedure

A solution of 213 (0.302 mmol, 127 mg) in CH3OH (1 mL) at 25° C. was treated with 30% Pd—C (25 mg) and then placed under a hydrogen atmosphere. The reaction mixture stirred for 12 h and then was filtered through a pad of celite. The solvents were removed in vacuo and the resulting oil was then treated with phenethyl bromide (1.5 equiv, 0.453 mmol, 62 μL) and K2CO3 (2.0 equiv, 0.604 mmol, 83 mg) in CH3CN (1.0 mL). The reaction mixture stirred for 12 h at 65° C. The reaction mixture was then purified directly by chromatography (PTLC, SiO2, 20 cm×20 cm, 1 mm, EtOAc-10% CH3OH) which provided 214 (51 mg, 118 mg theoretical, 43%) as colorless oil: Rf 0.45 (SiO2, EtOAc-10% CH3OH); LRMS m/z 390 (M+, C26H34N2O, requires 390).

Workup

  1. filtrationwas filtered through a pad of celite
  2. customThe solvents were removed in vacuo
  3. stirringThe reaction mixture stirred for 12 h at 65° C
  4. customThe reaction mixture was then purified directly by chromatography (PTLC, SiO2, 20 cm×20 cm, 1 mm, EtOAc-10% CH3OH) which

Sources & evidence

ORD record
ord-334b7849a2aa4225955f62ba36a589a1
Source dataset
uspto-grants-2004_01
Patent number
US06677332B1

Reaction notes

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